Specialized astrocytes mediate glutamatergic gliotransmission in the CNS.

ABSTRACT: Multimodal astrocyte-neuron communications govern brain circuitry assembly and function¹. For example, through rapid glutamate release, astrocytes can control excitability, plasticity and synchronous activity^2,3 of synaptic networks, while also contributing to their dysregulation in neuropsychiatric conditions^4-7. For astrocytes to communicate through fast focal glutamate release, they should possess an apparatus for Ca²⁺-dependent exocytosis similar to neurons^8-10. However, the existence of this mechanism has been questioned^11-13 owing to inconsistent data^14-17 and a lack of direct supporting evidence. Here we revisited the astrocyte glutamate exocytosis hypothesis by considering the emerging molecular heterogene

SUBMITTER: de Ceglia R 

PROVIDER: S-EPMC10550825 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature