Cingulate dynamics track depression recovery with deep brain stimulation.

ABSTRACT: Deep brain stimulation (DBS) of the subcallosal cingulate (SCC) can provide long-term symptom relief for treatment-resistant depression (TRD)¹. However, achieving stable recovery is unpredictable², typically requiring trial-and-error stimulation adjustments due to individual recovery trajectories and subjective symptom reporting³. We currently lack objective brain-based biomarkers to guide clinical decisions by distinguishing natural transient mood fluctuations from situations requiring intervention. To address this gap, we used a new device enabling electrophysiology recording to deliver SCC DBS to ten TRD participants (ClinicalTrials.gov identifier NCT01984710). At the study endpoint of 24 weeks, 90% of participants demonstrated robust clinical response,

SUBMITTER: Alagapan S 

PROVIDER: S-EPMC10550829 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature