Major histocompatibility complex compement (MHC) Bf alleles show trans species evolution between man and chimpanzee.

ABSTRACT: HLA and disease studies by using single allele statistics have been fruitless during the last 40 years for explaining association pathogenesis of the associated diseases.Other approaches are necessary to untangle this puzzle. We aim to revisit complement alleleism in humans and primates for both studying MHC and disease association to complotypes and extended MHC haplotypes in order to also explain the positive directional selection of maintaining immune response genes (complement, MHC adaptive and MHC non-specific genes) that keeps these three type of genes together in a short chromosome stretch (MHC) for million years. These genes may be linked to conjointly avoid microbes attack and autoimmunity. In the present paper, it is obtained a new Bf chimpanzee allele, provisionaly named Patr-Bf

SUBMITTER: Arnaiz-Villena A 

PROVIDER: S-EPMC10550962 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature