Disease-modifying therapies and features linked to treatment response in type 1 diabetes prevention: a systematic review.

ABSTRACT:

Background

Type 1 diabetes (T1D) results from immune-mediated destruction of insulin-producing beta cells. Prevention efforts have focused on immune modulation and supporting beta cell health before or around diagnosis; however, heterogeneity in disease progression and therapy response has limited translation to clinical practice, highlighting the need for precision medicine approaches to T1D disease modification.

Methods

To understand the state of knowledge in this area, we performed a systematic review of randomized-controlled trials with ≥50 participants cataloged in PubMed or Embase from the past 25 years testing T1D disease-modifying therapies and/or identifying features linked to treatment response, analyzing bias using a Cochrane-risk-of-bias instrument.

Results

SUBMITTER: Felton JL 

PROVIDER: S-EPMC10550983 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature