Identification of biomarkers in patients with rheumatoid arthritis responsive to DMARDs but with progressive bone erosion.

ABSTRACT:

Introduction

Rheumatoid arthritis (RA) is an inflammatory autoimmune disease that may cause joint destruction and disability. The pharmacological treatment of RA aims at obtaining disease remission by effectively ceasing joint inflammation and arresting progressive bone erosions. Some patients present bone lesions accrual even after controlling joint inflammation with current therapies. Our study aimed to analyze lymphocyte subsets and levels of circulating cytokines in patients with RA with progressive bone erosions.

Methods

We enrolled 20 patients with a diagnosis of RA and 12 healthy donors (HD). Patients with RA were divided into patients with bone erosions (RA-BE+) and without bone erosions (RA-BE-). Lymphocyte subsets in peripheral blood were evaluated by flow cytometr

SUBMITTER: Marasco E 

PROVIDER: S-EPMC10551039 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature