Wastewater-Based Surveillance of Antimicrobial Resistance in Niger: An Exploratory Study.

ABSTRACT: Wastewater-based surveillance is increasingly recognized as an important approach to monitoring population-level antimicrobial resistance (AMR). In this exploratory study, we examined the use of metagenomics to evaluate AMR using untreated wastewater samples routinely collected by the Niger national polio surveillance program. Forty-eight stored samples from two seasons each year over 4 years (2016-2019) in three regions were selected for inclusion in this study and processed using unbiased DNA deep sequencing. Normalized number of reads of genetic determinants for different antibiotic classes were compared over time, by season, and by location. Correlations in resistance were examined among classes. Changes in reads per million per year were demonstrated for several classes, including dec

SUBMITTER: Ousmane S 

PROVIDER: S-EPMC10551091 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature