Prevalence of genetic causes of obesity in clinical practice.

ABSTRACT:

Background

While obesity is common in the United States, monogenic obesity is rare, accounting for approximately 5% of individuals with obesity. New targeted therapies for genetic forms of obesity are available but there is limited guidance on who requires testing. The aims of this study were to evaluate the prevalence of potentially clinically significant variants among individuals in Pediatric Endocrinology or Medical Weight Center clinics at a single center and to identify clinical characteristics that may make genetic obesity more likely.

Methods

Children and adults who had a genetic test for obesity, Uncovering Rare Obesity Gene panel, ordered during routine clinic visits from December 2019 to March 2021 were identified.

Results

Of the 139 patients with testing o

SUBMITTER: Tamaroff J 

PROVIDER: S-EPMC10551116 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature