Altered intrinsic functional brain architecture in patients with functional constipation: a surface-based network study.

ABSTRACT:

Background

Functional constipation (FCon) is a common functional gastrointestinal disorder (FGID). Studies have indicated a higher likelihood of psychiatric disorders, such as anxiety, depression, sleep disturbances, and impaired concentration, among patients with FCon. However, the underlying pathophysiological mechanisms responsible for these symptoms in FCon patients remain to be fully elucidated. The human brain is a complex network architecture with several fundamental organizational properties. Neurological interactions between gut symptoms and psychiatric issues may be closely associated with these complex networks.

Methods

In the present study, a total of 35 patients with FCon and 40 healthy controls (HC) were recruited for a series of clinical examinations and resti

SUBMITTER: Yu X 

PROVIDER: S-EPMC10551127 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature