Insight into the relationship between resting heart rate and atrial fibrillation: a Mendelian randomization study.

ABSTRACT:

Aims

A low resting heart rate (RHR) implies a more efficient heart function and a lower risk of cardiovascular disease. However, observational studies have reported a U-shaped association between RHR and atrial fibrillation (AF). In contrast, Mendelian randomization (MR) studies have found an inverse causal association between RHR and AF. Hence, the causal nature of the relationship is not clear. The aim is to investigate the causal association and its shape between RHR on AF using linear and non-linear MR (NLMR).

Methods and results

Linear and non-linear MR were performed on individual-level data in the Trøndelag Health Study (HUNT) and UK Biobank (UKB). HUNT consists of 69 155 individuals with 7,062 AF cases, while UKB provides data on 431 852 individuals with 20 452 AF ca

SUBMITTER: Klevjer M 

PROVIDER: S-EPMC10551233 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature