Potential drug targets for asthma identified in the plasma and brain through Mendelian randomization analysis.

ABSTRACT:

Background

Asthma is a heterogeneous disease, and the involvement of neurogenic inflammation is crucial in its development. The standardized treatments focus on alleviating symptoms. Despite the availability of medications for asthma, they have proven to be inadequate in controlling relapses and halting the progression of the disease. Therefore, there is a need for novel drug targets to prevent asthma.

Methods

We utilized Mendelian randomization to investigate potential drug targets for asthma. We analyzed summary statistics from the UK Biobank and then replicated our findings in GWAS data by Demenais et al. and the FinnGen cohort. We obtained genetic instruments for 734 plasma and 73 brain proteins from recently reported GWAS. Next, we utilized reverse causal relationship a

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10551444 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature