Combination therapy with hydrogen peroxide and irradiation promotes an abscopal effect in mouse models.
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ABSTRACT: Hydrogen peroxide (H2 O2 ) induces oxidative stress and cytotoxicity, and can be used for treating cancers in combination with radiotherapy. A product comprising H2 O2 and sodium hyaluronate has been developed as a radiosensitizer. However, the effects of H2 O2 on antitumor immunity remain unclear. To investigate the effects of H2 O2 , especially the abscopal effect when combined with radiotherapy (RT), we implanted murine tumor cells simultaneously in two locations in mouse models: the hind limb and back. H2 O2 mixed with sodium hyaluronate was injected intratumorally, followed by irradiation only at the hind limb lesion. No treatment was administered to the back lesion. The H
SUBMITTER: Kemmotsu N
PROVIDER: S-EPMC10551598 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
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