Early zygotic gene product Dunk interacts with anillin to regulate Myosin II during Drosophila cleavage.

ABSTRACT: Drosophila melanogaster cellularization is a special form of cleavage that converts syncytial embryos into cellular blastoderms by partitioning the peripherally localized nuclei into individual cells. An early event in cellularization is the recruitment of nonmuscle myosin II ("myosin") to the leading edge of cleavage furrows, where myosin forms an interconnected basal array before reorganizing into individual cytokinetic rings. The initial recruitment and organization of basal myosin are regulated by a cellularization-specific gene, dunk, but the underlying mechanism is unclear. Through a genome-wide yeast two-hybrid screen, we identified anillin (Scraps in Drosophila), a conserved scaffolding protein in cytokinesis, as the primary binding partner of Dunk. Dunk coloca

SUBMITTER: Chen J 

PROVIDER: S-EPMC10551699 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature