A new layer of regulation of chromosomal passenger complex (CPC) translocation in budding yeast.

ABSTRACT: The conserved chromosomal passenger complex (CPC) consists of Ipl1^Aurora-B, Sli15^INCENP, Bir1^Survivin, and Nbl1^Borealin, and localizes at the kinetochore/centromere to correct kinetochore attachment errors and to prevent checkpoint silencing. After anaphase entry, the CPC moves from the kinetochore/centromere to the spindle. In budding yeast, CPC subunit Sli15 is phosphorylated by both cyclin-dependent kinase (CDK) and Ipl1 kinase. Following anaphase onset, activated Cdc14 phosphatase reverses Sli15 phosphorylation imposed by CDK to promote CPC translocation. Although abolished Sli15 phosphorylation imposed by Ipl1 also causes CPC translocation, the regulation of Ipl1-imposed Sli15 phosphorylation remains unclear. In addition to Sli15, Cdc14 also

SUBMITTER: Sherwin D 

PROVIDER: S-EPMC10551702 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature