Prophylactic Salpingo-Oophorectomy and Survival After BRCA1/2 Breast Cancer Resection.

ABSTRACT:

Importance

Few studies have investigated whether prophylactic salpingo-oophorectomy (PSO) for patients with previously resected breast cancer who carry pathogenic germline BRCA1 or BRCA2 variants is associated with a reduced risk of cancer-specific death.

Objective

To assess the association of PSO and prophylactic mastectomy (PM) with prognosis after quadrantectomy or mastectomy as primary treatment for patients with BRCA1 or BRCA2 breast cancer.

Design, setting, and participants

This retrospective cohort study was performed in a single-institution, tertiary referral center. Consecutive patients with invasive breast cancer treated surgically between 1972 and 2019 were recruited and followed up prospectively after they were found to carry the BRCA1 or BRCA2 gene varian

SUBMITTER: Martelli G 

PROVIDER: S-EPMC10551816 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature