Expression pattern, prognostic value and potential microRNA silencing of FZD8 in breast cancer.

ABSTRACT: Breast cancer (BC) is one of the most widespread types of cancer affecting females, and therefore, early diagnosis is critical. BC is a complex heterogeneous disease affected by several key pathways. Among these, WNT proteins and their frizzled receptors (FZD) have been demonstrated to be crucial in regulating a number of cellular and molecular events in BC tumorigenesis. The role of the WNT receptor, FZD8, in BC has received minimal attention; for that reason, the present study examined the prognostic value of its protein expression pattern in a BC cohort. FZD8 cytoplasmic expression pattern analysis revealed that ~38% of the primary samples presented with a high expression profile, whereas ~63% of the samples had a low expression profile. Overall, ~46% of the malignant tissues in the lym

SUBMITTER: Al-Zahrani MH 

PROVIDER: S-EPMC10551865 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature