Synthesis and Cytotoxicity of Monomethylated Betulinic Acid 3-O-α-l-Rhamnopyranosides.
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SUBMITTER: Gormand P
PROVIDER: S-EPMC10552092 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
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Synthesis and Cytotoxicity of Monomethylated Betulinic Acid 3-<i>O</i>-α-l-Rhamnopyranosides.
Gormand Paul P Pichette André A Legault Jean J Alsarraf Jérôme J
ACS omega 20230922 39
Three original derivatives of the cytotoxic betulinic acid 3-<i>O</i>-α-l-rhamnopyranoside featuring a monomethylated rhamnoside residue were synthesized. An improved catalytic procedure was involved to functionalize the <i>O</i>-3 position of the monosaccharide in a site-selective fashion. The cytotoxicity of the novel compounds was evaluated in vitro to highlight the moderate impact of carbohydrate monomethylation on the biological activity of betulinic acid 3-<i>O</i>-α-l-rhamnopyranoside. ...[more]
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