Decoding cell-type contributions to the cfRNA transcriptomic landscape of liver cancer.

ABSTRACT:

Background

Liquid biopsy, particularly cell-free RNA (cfRNA), has emerged as a promising non-invasive diagnostic tool for various diseases, including cancer, due to its accessibility and the wealth of information it provides. A key area of interest is the composition and cellular origin of cfRNA in the blood and the alterations in the cfRNA transcriptomic landscape during carcinogenesis. Investigating these changes can offer insights into the manifestations of tissue alterations in the blood, potentially leading to more effective diagnostic strategies. However, the consistency of these findings across different studies and their clinical utility remains to be fully elucidated, highlighting the need for further research in this area.

Results

In this study, we analyzed over 35

SUBMITTER: Safrastyan A 

PROVIDER: S-EPMC10552294 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature