RAD51 is a poor prognostic marker and a potential therapeutic target for oral squamous cell carcinoma.

ABSTRACT:

Objectives

RAD51 overexpression has been reported to serve as a marker of poor prognosis in several cancer types. This study aimed to survey the role of RAD51 in oral squamous cell carcinoma and whether RAD51 could be a potential therapeutic target.

Materials and methods

RAD51 protein expression, assessed by immunohistochemical staining, was used to examine associations with survival and clinicopathological profiles of patients with oral squamous cell carcinoma. Lentiviral infection was used to knock down or overexpress RAD51. The influence of RAD51 on the biological profile of oral cancer cells was evaluated. Cell viability and apoptosis after treatment with chemotherapeutic agents and irradiation were analyzed. Co-treatment with chemotherapeutic agents and B02, a RAD51 inh

SUBMITTER: Tsai YF 

PROVIDER: S-EPMC10552296 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature