Impacts of maternal microbiota and microbial metabolites on fetal intestine, brain, and placenta.

ABSTRACT:

Background

The maternal microbiota modulates fetal development, but the mechanisms of these earliest host-microbe interactions are unclear. To investigate the developmental impacts of maternal microbial metabolites, we compared full-term fetuses from germ-free and specific pathogen-free mouse dams by gene expression profiling and non-targeted metabolomics.

Results

In the fetal intestine, critical genes mediating host-microbe interactions, innate immunity, and epithelial barrier were differentially expressed. Interferon and inflammatory signaling genes were downregulated in the intestines and brains of the fetuses from germ-free dams. The expression of genes related to neural system development and function, translation and RNA metabolism, and regulation of energy metabolism

SUBMITTER: Husso A 

PROVIDER: S-EPMC10552303 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature