Mycothiol maintains the homeostasis and signalling of nitric oxide in Streptomyces coelicolor A3(2) M145.

ABSTRACT:

Background

Previous studies have revealed a nitric oxide (NO) metabolic cycle in which NO, nitrate (NO₃^-), and nitrite (NO₂^-) circulate. The NO produced in this cycle serves as a signalling molecule that regulates actinorhodin (ACT) production via the DevS/DevR NO-dependent two-component system (TCS) in Streptomyces coelicolor A3(2) M145. However, the mechanisms involved in the regulation of NO signalling in S. coelicolor have not yet been elucidated. Mycothiol (MSH), a thiol molecule produced by Actinomyces, is involved in the defence mechanisms against oxidative stress. Therefore, this study focused on the correlation between intracellular NO and MSH levels.

Results

To investigate the interaction of MSH with endogenously produced

SUBMITTER: Yoshizumi T 

PROVIDER: S-EPMC10552308 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature