A blinded, randomized and controlled multicenter clinical trial to assess the efficacy and safety of Leisguard^® as an immunotherapeutic treatment for healthy Leishmania infantum-seropositive dogs.

ABSTRACT:

Background

Domperidone (Leisguard^®) is an immunomodulatory drug used as a preventive measure in healthy dogs. However, no studies have been published in healthy Leishmania infantum-seropositive dogs. The aim of this study was to evaluate the clinical efficacy and safety of domperidone as immunotherapy in Leishmania-seropositive healthy dogs.

Methods

Sixty-seven dogs were treated with domperidone at 0.5 mg/kg and 44 dogs received placebo, once daily for 4 consecutive weeks. Monthly treatments were repeated every 4 months until the end of the 1-year follow-up period. Veterinary examinations were performed on days 0, 30, 120, 150, 240, 270 and 360. Samples of blood and urine were collected on days 0, 120, 240 and 360 for routine laboratory tests and quantitative in-h

SUBMITTER: Baxarias M 

PROVIDER: S-EPMC10552330 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature