Alterations in gut microbiome and metabolite profile of patients with Schistosoma japonicum infection.

ABSTRACT:

Background

Schistosoma infection is a significant public health issue, affecting over 200 million individuals and threatening 700 million people worldwide. The species prevalent in China is Schistosoma japonicum. Recent studies showed that both gut microbiota and metabolome are closely related to schistosomiasis caused by S. japonicum, but clinical study is limited and the underlying mechanism is largely unclear. This study aimed to explore alterations as well as function of gut microbiota and metabolite profile in the patients with S. japonicum infection.

Methods

This study included 20 patients diagnosed with chronic schistosomiasis caused by S. japonicum, eight patients with advanced schistosomiasis caused by S. japonicum and 13 healthy volunteers. The fresh feces of these

SUBMITTER: Zhou C 

PROVIDER: S-EPMC10552355 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature