Efficient expansion and delayed senescence of hUC-MSCs by microcarrier-bioreactor system.

ABSTRACT:

Background

Human umbilical cord mesenchymal stem cells (hUC-MSCs) are widely used in cell therapy due to their robust immunomodulatory and tissue regenerative capabilities. Currently, the predominant method for obtaining hUC-MSCs for clinical use is through planar culture expansion, which presents several limitations. Specifically, continuous cell passaging can lead to cellular aging, susceptibility to contamination, and an absence of process monitoring and control, among other limitations. To overcome these challenges, the technology of microcarrier-bioreactor culture was developed with the aim of ensuring the therapeutic efficacy of cells while enabling large-scale expansion to meet clinical requirements. However, there is still a knowledge gap regarding the comparison of biologi

SUBMITTER: Wang X 

PROVIDER: S-EPMC10552362 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature