The Biomarker Toolkit - an evidence-based guideline to predict cancer biomarker success and guide development.

ABSTRACT:

Background

An increased number of resources are allocated on cancer biomarker discovery, but very few of these biomarkers are clinically adopted. To bridge the gap between Biomarker discovery and clinical use, we aim to generate the Biomarker Toolkit, a tool designed to identify clinically promising biomarkers and promote successful biomarker translation.

Methods

All features associated with a clinically useful biomarker were identified using mixed-methodology, including systematic literature search, semi-structured interviews, and an online two-stage Delphi-Survey. Validation of the checklist was achieved by independent systematic literature searches using keywords/subheadings related to clinically and non-clinically utilised breast and colorectal cancer biomarkers. Composi

SUBMITTER: Savva KV 

PROVIDER: S-EPMC10552368 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature