Resveratrol: a potential medication for the prevention and treatment of varicella zoster virus-induced ischemic stroke.

ABSTRACT:

Background

Infection rate of varicella zoster virus (VZV) is 95% in humans, and VZV infection is strongly associated with ischemic stroke (IS). However, the underlying molecular mechanisms of VZV-induced IS are still unclear, and there are no effective agents to treat and prevent VZV-induced IS.

Objective

By integrating bioinformatics, this study explored the interactions between VZV and IS and potential medication to treat and prevent VZV-induced IS.

Methods

In this study, the VZV and IS datasets from the GEO database were used to specify the common genes. Then, bioinformatics analysis including Gene Ontology, Kyoto Encyclopedia Genes Genomes and Protein-Protein Interaction network analysis was performed. Further, the hub genes, transcription factor (TF) gene interac

SUBMITTER: Wang X 

PROVIDER: S-EPMC10552394 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature