The neuroanatomical substrates of autism and ADHD and their link to putative genomic underpinnings.

ABSTRACT:

Background

Autism spectrum disorders (ASD) are neurodevelopmental conditions accompanied by differences in brain development. Neuroanatomical differences in autism are variable across individuals and likely underpin distinct clinical phenotypes. To parse heterogeneity, it is essential to establish how the neurobiology of ASD is modulated by differences associated with co-occurring conditions, such as attention-deficit/hyperactivity disorder (ADHD). This study aimed to (1) investigate between-group differences in autistic individuals with and without co-occurring ADHD, and to (2) link these variances to putative genomic underpinnings.

Methods

We examined differences in cortical thickness (CT) and surface area (SA) and their genomic associations in a sample of 533 individuals

SUBMITTER: Berg LM 

PROVIDER: S-EPMC10552404 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature