Identification of Indicative Gut Microbial Guilds in a Natural Aging Mouse Model.

ABSTRACT: Gut microbial dysbiosis during later life may contribute to health conditions, possibly due to an increase in intestinal permeability, immune changes, and systemic inflammation. Mouse models have been employed to determine the influence of gut microbes on aging; however, suitable gut microbial indicators are currently lacking. Therefore, this study aimed to determine the gut microbial indicators and their potential guilds in a natural aging mouse model. In agreement with previous studies, alpha diversity indices-including observed OTUs, ACE, Chao1, and Simpson-were significantly lower in aged mice than in younger mice. The results of beta diversity analysis revealed the compositional differences between young and aged mice, and the MRPP, ANOSIM, and Adonis tests indicated that the results

SUBMITTER: Koh YC 

PROVIDER: S-EPMC10552476 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature