Synthesis of Peptidyl-tRNA Mimics for Structural Biology Applications.

ABSTRACT: ConspectusProtein biosynthesis is a central process in all living cells that is catalyzed by a complex molecular machine─the ribosome. This process is termed translation because the language of nucleotides in mRNAs is translated into the language of amino acids in proteins. Transfer RNA (tRNA) molecules charged with amino acids serve as adaptors and recognize codons of mRNA in the decoding center while simultaneously the individual amino acids are assembled into a peptide chain in the peptidyl transferase center (PTC). As the nascent peptide emerges from the ribosome, it is threaded through a long tunnel referred to as a nascent peptide exit tunnel (NPET). The PTC and NPET are the sites targeted by many antibiotics and are thus of tremendous importance from a biomedical perspective and for

SUBMITTER: Polikanov YS 

PROVIDER: S-EPMC10552525 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature