Widespread and dynamic expression of granzyme C by skin-resident antiviral T cells.

ABSTRACT: After recognition of cognate antigen (Ag), effector CD8⁺ T cells secrete serine proteases called granzymes in conjunction with perforin, allowing granzymes to enter and kill target cells. While the roles for some granzymes during antiviral immune responses are well characterized, the function of others, such as granzyme C and its human ortholog granzyme H, is still unclear. Granzyme C is constitutively expressed by mature, cytolytic innate lymphoid 1 cells (ILC1s). Whether other antiviral effector cells also produce granzyme C and whether it is continually expressed or responsive to the environment is unknown. To explore this, we analyzed granzyme C expression in different murine skin-resident antiviral lymphocytes. At steady-state, dendritic epidermal T cells (DETCs) expressed

SUBMITTER: Lujan RA 

PROVIDER: S-EPMC10552530 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature