Metal Binding of Alzheimer's Amyloid-β and Its Effect on Peptide Self-Assembly.

ABSTRACT: ConspectusMetal ions have been identified as key factors modulating the aggregation of amyloid-β peptide (Aβ) implicated in Alzheimer's disease (AD). The presence of elevated levels of metal ions in the amyloid plaques in AD patients supports the notion that the dysfunction of metal homeostasis is connected to the development of AD pathology. Here, recent findings from high- and low-resolution biophysical techniques are put into perspective, providing detailed insights into the molecular structures and dynamics of metal-bound Aβ complexes and the effect of metal ions on the Aβ aggregation process. In particular, the development of theoretical kinetic models deducing different microscopic nucleation events from the macroscopic aggregation behavior has enabled deciphering of the effect of me

SUBMITTER: Abelein A 

PROVIDER: S-EPMC10552549 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature