IGJ suppresses breast cancer growth and metastasis by inhibiting EMT via the NF‑κB signaling pathway.

ABSTRACT: Breast cancer metastasis is the primary cause of mortality of patients with breast cancer. The present study aimed to explore the role and underlying mechanisms of IGJ in the invasion and metastasis of breast cancer. The Cancer Genome Atlas database was utilized to analyze the differential gene expression profiles in patients with breast cancer with or without metastasis; the target gene, joining chain of multimeric IgA and IgM (JCHAIN, also known as IGJ, as referred to herein), with significant expression and with prognostic value was screened. The expression levels of IGJ in human breast cancer paired tissues and cell lines were detected using reverse transcription‑quantitative PCR and western blot analysis. IGJ differential expression was detected in paired human breast cancer tissues u

SUBMITTER: Wang M 

PROVIDER: S-EPMC10552693 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature