Overexpression of SERPINA3 suppresses tumor progression by modulating SPOP/NF‑κB in lung cancer.

ABSTRACT: The pathogenesis mechanism of lung cancer is very complex, with high incidence and mortality. Serpin family A member 3 (SERPINA3) expression levels were reduced in the sera of patients with lung cancer and may be a candidate diagnostic and prognostic survival biomarker in lung cancer, as previously reported. However, the detailed biological functions of SERPINA3 in the pathogenesis of lung cancer remain unknown. In the present study, it was aimed to explore the effects of SERPINA3 on the occurrence of lung cancer. SERPINA3 expression was assessed using bioinformatics database analysis and experimental detection. Then, the biological effects of SERPINA3 were investigated in a cell culture system and a xenograft model of human lung cancer. The potential regulatory mechanism of SERPINA3 in lu

SUBMITTER: Jin Y 

PROVIDER: S-EPMC10552721 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature