RBM15‑mediating MDR1 mRNA m⁶A methylation regulated by the TGF‑β signaling pathway in paclitaxel‑resistant ovarian cancer.

ABSTRACT: Ovarian cancer (OC) lacks effective biomarkers for diagnosis at an early stage and often develops chemoresistance after the initial treatment at an advanced stage. RNA‑binding motif protein 15 (RBM15) is an RNA m6A methylation mediator that serves an oncogenic role in some cancers. However, the function and molecular mechanisms of RBM15 in ovarian tumorigenesis and chemoresistance remain to be elucidated. The present study identified the overexpression of RBM15 in OC tissues and paclitaxel (PTX)‑resistant cells using reverse transcription‑quantitative (q)PCR, western blotting and immunohistochemistry. Clinical data analyses showed that high expression of RBM15 was associated with poor prognosis in patients with OC. Overexpression of RBM15 led to an increase in cell viability and colony for

SUBMITTER: Yuan J 

PROVIDER: S-EPMC10552772 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature