Fetoplacental vascular effects of maternal adrenergic antihypertensive and cardioprotective medications in pregnancy.

ABSTRACT: Maternal cardiovascular diseases, including hypertension and cardiac conditions, are associated with poor fetal outcomes. A range of adrenergic antihypertensive and cardioprotective medications are often prescribed to pregnant women to reduce major maternal complications during pregnancy. Although these treatments are not considered teratogenic, they may have detrimental effects on fetal growth and development, as they cross the fetoplacental barrier, and may contribute to placental vascular dysregulation. Medication risk assessment sheets do not include specific advice to clinicians and women regarding the safety of these therapies for use in pregnancy and the potential off-target effects of adrenergic medications on fetal growth have not been rigorously conducted. Little is known of thei

SUBMITTER: Tropea T 

PROVIDER: S-EPMC10552840 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature