Characterization of Anxiety-Like Behaviors and Neural Circuitry following Chronic Moderate Noise Exposure in Mice.

ABSTRACT:

Background

Commonly encountered nontraumatic, moderate noise is increasingly implicated in anxiety; however, the neural substrates underlying this process remain unclear.

Objectives

We investigated the neural circuit mechanism through which chronic exposure to moderate-level noise causes anxiety-like behaviors.

Methods

Mice were exposed to chronic, moderate white noise [85 decibel (dB) sound pressure level (SPL)], 4 h/d for 4 wk to induce anxiety-like behaviors, which were assessed by open field, elevated plus maze, light-dark box, and social interaction tests. Viral tracing, immunofluorescence confocal imaging, and brain slice patch-clamp recordings were used to characterize projections from auditory brain regions to the lateral amygdala. Neuronal activities were cha

SUBMITTER: Peng X 

PROVIDER: S-EPMC10552915 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature