Identification of key genes associated with poor prognosis and neoplasm staging in gastric cancer.

ABSTRACT:

Background

Gastric cancer (GC) is highly biologically and genetically heterogeneous disease with poor prognosis. Increasing evidence indicates that biomarkers can serve as prediction and clinical intervention. Therefore, it is vital to identify core molecules and pathways participating in the development of GC.

Methods

In this study, GSE54129, GSE56807, GSE63089, and GSE118916 were used for identified overlapped 75 DEGs. GO and Kyoto Encyclopedia of Genes and Genomes pathway analysis showed DEGs mainly enriched in biological process about collagen-containing extracellular matrix and collagen metabolic. Next, protein-protein interaction network was built and the hub gene was excavated. Clinicopathological features and prognostic value were also evaluated.

Results

Hub g

SUBMITTER: Wang S 

PROVIDER: S-EPMC10553055 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature