Lansoprazole plus levosulpiride versus esomeprazole in participants with gastroesophageal reflux disease and erosive esophagitis: a double blinded randomized control trial.

ABSTRACT:

Aim

The aim was to compare the efficacy and safety of lansoprazole plus levosulpiride over esomeprazole.

Methodology

This randomized control trial recruited 1000 participants having symptomatic gastroesophageal reflux disease (GERD) and erosive esophagitis and they were blindly randomized into two groups in a 1:1 ratio with appropriate concealment. Group 1 was given lansoprazole plus levosulpiride combination twice daily whereas group 2 was prescribed only esomeprazole twice daily. The primary efficacy endpoint was the healing of erosive esophagitis and GERD at week 49. Secondary assessments included improvement in quality of life. Participants' quality of life was assessed before starting the treatment and post-treatment using a short-form health survey questionnaire (SF-36

SUBMITTER: Umer MR 

PROVIDER: S-EPMC10553095 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature