Lack of association of the alpha-ketoglutarate-dependent dioxygenase (FTO) gene polymorphisms with pulmonary tuberculosis risk: a systematic review and meta-analysis.

ABSTRACT:

Objective

Our meta-analysis aims to explore the association of two single nucleotide variants; rs9939609 and rs8050136, within the FTO gene with risk of pulmonary tuberculosis (PTB).

Methods

The association of two single nucleotide variants with PTB in three genetic models was evaluated using pooled odds ratios (ORs) with 95% CIs.

Results

No significant association was observed between the rs9939609 polymorphism and PTB when assuming an allelic model (OR: 1.10; 95% CI: 0.85-1.41; P=0.47; I² = 64.98%), a recessive model (OR: 2.04; 95% CI: 0.87-4.77; P=0.10; I² = 67.18%), or a dominant model (OR: 0.96; 95% CI: 0.83-1.11; P=0.56; I² = 27.45%). Likewise, no association was observed between rs8050136 polymorphism and PT

SUBMITTER: Lamichhane P 

PROVIDER: S-EPMC10553135 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature