Identifying patients with multidrug-resistant tuberculosis who may benefit from shorter durations of treatment.

ABSTRACT:

Objective

Studying treatment duration for rifampicin-resistant and multidrug-resistant tuberculosis (MDR/RR-TB) using observational data is methodologically challenging. We aim to present a hypothesis generating approach to identify factors associated with shorter duration of treatment.

Study design and setting

We conducted an individual patient data meta-analysis among MDR/RR-TB patients restricted to only those with successful treatment outcomes. Using multivariable linear regression, we estimated associations and their 95% confidence intervals (CI) between the outcome of individual deviation in treatment duration (in months) from the mean duration of their treatment site and patient characteristics, drug resistance, and treatments used.

Results

Overall, 6702 patien

SUBMITTER: Winters N 

PROVIDER: S-EPMC10553332 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature