Spatial regulation of Drosophila ovarian Follicle Stem Cell division rates and cell cycle transitions.

ABSTRACT: Drosophila ovarian Follicle Stem Cells (FSCs) present a favorable paradigm for understanding how stem cell division and differentiation are balanced in communities where those activities are independent. FSCs also allow exploration of how this balance is integrated with spatial stem cell heterogeneity. Posterior FSCs become proliferative Follicle Cells (FCs), while anterior FSCs become quiescent Escort Cells (ECs) at about one fourth the frequency. A single stem cell can nevertheless produce both FCs and ECs because it can move between anterior and posterior locations. Studies based on EdU incorporation to approximate division rates suggested that posterior FSCs divide faster than anterior FSCs. However, direct measures of cell cycle times are required to ascertain whether FC output requir

SUBMITTER: Melamed D 

PROVIDER: S-EPMC10553835 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature