Ontology highlight
ABSTRACT:
SUBMITTER: Mack AH
PROVIDER: S-EPMC10553922 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
Mack Andrew H AH Menzies Georgina G Southgate Alex A Jones D Dafydd DD Connor Thomas R TR
Molecular biology and evolution 20231001 10
The RNA-dependent RNA polymerase of the severe acute respiratory syndrome coronavirus 2 virus is error prone, with errors being corrected by the exonuclease (NSP14) proofreading mechanism. However, the mutagenesis and subsequent evolutionary trajectory of the virus is mediated by the delicate interplay of replicase fidelity and environmental pressures. Here, we have shown that a single, distal mutation (F60S) in NSP14 can have a profound impact upon proofreading with an increased accumulation of ...[more]