Identification of Plasma Biomarkers in Drug-Naive Schizophrenia Using Targeted Metabolomics.

ABSTRACT:

Objective

Schizophrenia (SCZ) is a severe psychiatric disorder with unknown etiology and lacking specific biomarkers. Herein, we aimed to explore plasma biomarkers relevant to SCZ using targeted metabolomics.

Methods

Sixty drug-naïve SCZ patients and 36 healthy controls were recruited. Psychotic symptoms were assessed using the Positive and Negative Syndrome Scale. We analyzed the levels of 271 metabolites in plasma samples from all subjects using targeted metabolomics, and identified metabolites that differed significantly between the two groups. Then we evaluated the diagnostic power of the metabolites based on receiver operating characteristic curves, and explored metabolites associated with the psychotic symptoms in SCZ patients.

Results

Twenty-six metabolites sho

SUBMITTER: Su Q 

PROVIDER: S-EPMC10555515 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature