Subtype-Based Microbial Analysis in Non-small Cell Lung Cancer.

ABSTRACT:

Background

The human lung serves as a niche for a unique and dynamic bacterial community related to the development and aggravation of multiple respiratory diseases. Therefore, identifying the microbiome status is crucial to maintaining the microecological balance and maximizing the therapeutic effect on lung diseases. Therefore, we investigated the histological type-based differences in the lung microbiomes of patients with lung cancer.

Methods

We performed 16S rRNA sequencing to evaluate the respiratory tract microbiome present in bronchoalveolar lavage fluid. Patients with non-small cell lung cancer were stratified based on two main subtypes of lung cancer: adenocarcinoma and squamous cell carcinoma (SqCC).

Results

Among the 84 patients analyzed, 64 (76.2%) had ade

SUBMITTER: Jang HJ 

PROVIDER: S-EPMC10555521 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature