Drinking alkaline mineral water confers diarrhea resistance in maternally separated piglets by maintaining intestinal epithelial regeneration via the brain-microbe-gut axis.

ABSTRACT:

Introduction

Diarrhea has the fourth-highest mortality rate of all diseases and causes a large number of infant deaths each year. The maternally separated (MS) piglet (newly weaned piglet) is an excellent model to investigate the treatment of diarrhea in infants. Drinking alkaline mineral water has the potential to be therapeutic in gastrointestinal disorders, particularly diarrhea, but the supporting evidence from system studies and the mechanisms involved have yet to be reported.

Objectives

This study aims to determine whether drinking alkaline mineral water confers diarrhea resistance in MS piglets under weaning stress and what the fundamental mechanisms involved are.

Methods

MS piglets were used to create a stress-induced intestinal disorder-diarrhea susceptibilit

SUBMITTER: Chen J 

PROVIDER: S-EPMC10555785 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature