Educational attainment, health outcomes and mortality: a within-sibship Mendelian randomization study.

ABSTRACT:

Background

Previous Mendelian randomization (MR) studies using population samples (population MR) have provided evidence for beneficial effects of educational attainment on health outcomes in adulthood. However, estimates from these studies may have been susceptible to bias from population stratification, assortative mating and indirect genetic effects due to unadjusted parental genotypes. MR using genetic association estimates derived from within-sibship models (within-sibship MR) can avoid these potential biases because genetic differences between siblings are due to random segregation at meiosis.

Methods

Applying both population and within-sibship MR, we estimated the effects of genetic liability to educational attainment on body mass index (BMI), cigarette smoking, systo

SUBMITTER: Howe LJ 

PROVIDER: S-EPMC10555788 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature