D-LMBmap: a fully automated deep-learning pipeline for whole-brain profiling of neural circuitry.

ABSTRACT: Recent proliferation and integration of tissue-clearing methods and light-sheet fluorescence microscopy has created new opportunities to achieve mesoscale three-dimensional whole-brain connectivity mapping with exceptionally high throughput. With the rapid generation of large, high-quality imaging datasets, downstream analysis is becoming the major technical bottleneck for mesoscale connectomics. Current computational solutions are labor intensive with limited applications because of the exhaustive manual annotation and heavily customized training. Meanwhile, whole-brain data analysis always requires combining multiple packages and secondary development by users. To address these challenges, we developed D-LMBmap, an end-to-end package providing an integrated workflow containing three modu

SUBMITTER: Li Z 

PROVIDER: S-EPMC10555838 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature