Evidence Accumulation and Neural Correlates of Uncertainty in Obsessive-Compulsive Disorder.

ABSTRACT:

Background

Decision making is frequently associated with risk taking under uncertainty. Elevated intolerance of uncertainty is suggested to be a critical feature of obsessive-compulsive disorder (OCD). However, impairments of latent constructs of uncertainty processing and its neural correlates remain unclear in OCD.

Methods

In 83 participants (24 OCD patients treated with capsulotomy, 28 OCD control participants, and 31 healthy control participants), we performed magnetic resonance imaging using a card gambling task in which participants made decisions whether to bet or not that the next card would be larger than the current one. A hierarchical drift diffusion model was used to dissociate speed and amount of evidence accumulated before a decisional threshold (i.e., betting

SUBMITTER: Zhao YJ 

PROVIDER: S-EPMC10555851 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature