Life course effects of genetic susceptibility to higher body size on body fat and lean mass: prospective cohort study.

ABSTRACT:

Background/objectives

Different genetic variants are associated with larger body size in childhood vs adulthood. Whether and when these variants predominantly influence adiposity are unknown. We examined how genetic variants influence total body fat and total lean mass trajectories.

Methods

Data were from the Avon Longitudinal Study of Parents and Children birth cohort (N = 6926). Sex-specific genetic risk scores (GRS) for childhood and adulthood body size were generated, and dual-energy X-ray absorptiometry scans measured body fat and lean mass six times between the ages of 9 and 25 years. Multilevel linear spline models examined associations of GRS with fat and lean mass trajectories.

Results

In males, the sex-specific childhood and adulthood GRS were associated wit

SUBMITTER: Waterfield S 

PROVIDER: S-EPMC10555894 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature