The anti-inflammatory effect of dimethyl trisulfide in experimental acute pancreatitis.

ABSTRACT: Various organosulfur compounds, such as dimethyl trisulfide (DMTS), display anti-inflammatory properties. We aimed to examine the effects of DMTS on acute pancreatitis (AP) and its mechanism of action in both in vivo and in vitro studies. AP was induced in FVB/n mice or Wistar rats by caerulein, ethanol-palmitoleic acid, or L-ornithine-HCl. DMTS treatments were administered subcutaneously. AP severity was assessed by pancreatic histological scoring, pancreatic water content, and myeloperoxidase activity measurements. The behaviour of animals was followed. Pancreatic heat shock protein 72 (HSP72) expression, sulfide, and protein persulfidation were measured. In vitro acinar viability, intracellular Ca²⁺ concentration, and reactive oxygen species production were determined. DMTS d

SUBMITTER: Orjan EM 

PROVIDER: S-EPMC10556037 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature