NK cells from Men Who Have Sex with Men at high risk for HIV-1 infection exhibit higher effector capacity.

ABSTRACT: Despite being under constant exposure to HIV-1, some individuals do not show serological or clinical evidence of infection and are known as HESN (HIV-Exposed Seronegative). Multiple studies in different HESN cohorts have linked the NK cells as a correlate of resistance; however, little is known about the role of these cells in Men Who Have Sex with Men (MSM) with high risk sexual behaviors. We evaluated a general overview of activation and effector features of NK cells of MSM co-cultured with LT CD4⁺ HIV⁺ in which MSM at high risk of HIV-1 infection (HR-MSM) exhibit higher capacity to eliminate infected cells, reduced percentages of CD69⁺ cells when compared to MSM at low risk of infection (LR-MSM). In addition, we found that, despite the lower levels of CD

SUBMITTER: Rincon DS 

PROVIDER: S-EPMC10556081 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature